Tryptophan Literature - Tryptophan for Central Serotonin Synthesis

Literature - Which Factors Affect the Availability of Tryptophan for Central Serotonin Synthesis?


1. Badawy AA, Doughrty DM, Marsh-Richard DM, Steptoe A. Activation of Liver Tryptophan Pyrrolase Mediates the Decrease in Tryptophan Availability to the Brain after Acute Alcohol Consumption by Normal Subjects. Alcohol Alcohol. 2009 Feb 20.

2. Banerjee T, Duhadaway JB, Gaspari P, Sutanto-Ward E, Munn DH, Mellor AL, Malachowski WP, Prendergast GC, Muller AJ. A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase. Oncogene. 2008 May 1;27(20):2851-7.

3. Blomstrand E, Hassmén P, Ekblom B, Newsholme EA. Administration of branched-chain amino acids during sustained exercise-effects on performance and on plasma concentration of some amino acids. Eur J Appl Physiol Occup Physiol. 1991;63(2):83-8.

4. Blomstrand E, Møller K, Secher NH, Nybo L. Effect of carbohydrate ingestion on brain exchange of amino acids during sustained exercise in human subjects. Acta Physiol Scand. 2005 Nov;185(3):203-9.

5. Caperuto EC, dos Santos RV, Mello MT, Costa Rosa LF. Effect of endurance training on hypothalamic serotonin concentration and performance. Clin Exp Pharmacol Physiol. 2009 Feb;36(2):189-91.

6. Chaouloff F. Effects of acute physical exercise on central serotonergic systems. Med Sci Sports Exerc. 1997 Jan;29(1):58-62. Review.

7. Daya S, Anoopkumar-Dukie S. Acetaminophen inhibits liver trytophan-2,3-dioxygenase activity with a concomitant rise in brain serotonin levels and a reduction in urinary 5-hydroxyindole acetic acid. Life Sci. 2000 Jun 8;67(3):235-40.

8. Durlach J, Pagès N, Bac P, Bara M, Guiet-Bara A Biorhythms and possible central regulation of magnesium status, phototherapy, darkness therapy and chronopathological forms of magnesium depletion. Magnes Res. 2002 Mar;15(1-2):49-66.

9. Fernstrom JD, Wurtman RJ. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 1972 Oct 27;178(59):414-6.

10. Franklin M, Odontiadis J. Effects of treatment with chromium picolinate on peripheral amino acid availability and brain monoamine function in the rat. Pharmacopsychiatry. 2003 Sep;36(5):176-80.

11. Green AR, Aronson JK, Curzon G, Woods HF. Metabolism of an oral tryptophan load. I: Effects of dose and pretreatment with tryptophan. Br J Clin Pharmacol. 1980 Dec;10(6):603-10.

12. Henderson GC, Fattor JA, Horning MA, Faghihnia N, Johnson ML, Mau TL, Luke-Zeitoun M, Brooks GA. Lipolysis and fatty acid metabolism in men and women during the postexercise recovery period. J Physiol. 2007 Nov 1;584(Pt 3):963-81.

13. Heuther G, Hajak G, Reimer A, Poeggeler B, Blömer M, Rodenbeck A, Rüther E. The metabolic fate of infused L-tryptophan in men: possible clinical implications of the accumulation of circulating tryptophan and tryptophan metabolites. Psychopharmacology (Berl). 1992;109(4):422-32.

14. Hirota T, Hirota K, Sanno Y, Tanaka T. A new glucocorticoid receptor species: relation to induction of tryptophan dioxygenase by glucocorticoids. Endocrinology. 1985 Nov;117(5):1788-95.

15. Hvas AM, Juul S, Bech P, Nexø E. Vitamin B6 level is associated with symptoms of depression. Psychother Psychosom. 2004 Nov-Dec;73(6):340-3.

16. Jenny M, Santer E, Klein A, Ledochowski M, Schennach H, Ueberall F, Fuchs D. Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells. J Ethnopharmacol. 2009 Mar 18;122(2):261-7.

17. Jeong YI, Kim SW, Jung ID, Lee JS, Chang JH, Lee CM, Chun SH, Yoon MS, Kim GT, Ryu SW, Kim JS, Shin YK, Lee WS, Shin HK, Lee JD, Park YM. Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells. J Biol Chem. 2009 Feb 6;284(6):3700-8.

18. Kamanna VS, Kashyap ML. Nicotinic acid (niacin) receptor agonists: will they be useful therapeutic agents? Am J Cardiol. 2007 Dec 3;100(11 A):S53-61. Review.

19. Kaneko M, Watanabe K, Kumashiro H. Plasma ratios of tryptophan and tyrosine to other large neutral amino acids in manic-depressive patients. Jpn J Psychiatry Neurol. 1992 Sep;46(3):711-20.

20. Korbitz BC. Tryptophan metabolism in the magnesium deficient rat. J Vitaminol (Kyoto). 1970 Jun 10;16(2):140-3.

21. Lee HJ, Jeong YI, Lee TH, Jung ID, Lee JS, Lee CM, Kim JI, Joo H, Lee JD, Park YM. Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Biochem Pharmacol. 2007 May 1;73(9):1412-21. Epub 2006 Dec 20.

22. Lenard NR, Gettys TW, Dunn AJ. Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan. J Pharmacol Exp Ther. 2003 May;305(2):653-9. Epub 2003 Jan 24.

23. Lim BV, Jang MH, Shin MC, Kim HB, Kim YJ, Kim YP, Chung JH, Kim H, Shin MS, Kim SS, Kim EH, Kim CJ. Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats. Neurosci Lett. 2001 Jul 27;308(1):25-8.

24. Maharaj H, Maharaj DS, Saravanan KS, Mohanakumar KP, Daya S. Aspirin curtails the acetaminophen-induced rise in brain norepinephrine levels. Metab Brain Dis. 2004 Jun;19(1-2):71-7.

25. Markus CR, Firk C, Gerhardt C, Kloek J, Smolders GJ. Effect of different tryptophan sources on amino acid availability to the brain and mood in healty volunteers. Psychopharmcol 2008;201:107-114.

26. Meeusen R, Thorré K, Chaouloff F, Sarre S, De Meirleir K, Ebinger G, Michotte Y. Effects of tryptophan and/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats. Brain Res. 1996 Nov 18;740(1-2):245-52.

27. Miura H, Ozaki N, Sawada M, Isobe K, Ohta T, Nagatsu T. A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression.Stress. 2008;11(3):198-209. Review.

28. Möller SE. Pharmacokinetics of tryptophan, renal handling of kynurenine and the effect of nicotinamide on its appearance in plasma and urine following L-tryptophan loading of healthy subjects. Eur J Clin Pharmacol. 1981;21(2):137-42.

29. Möller SE. Tryptophan to competing amino acids ratio in depressive disorder: relation to efficacy of antidepressive treatments. Acta Psychiatr Scand Suppl. 1985;325:3-31. Review.

30. Penberthy WT. Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease. Curr Drug Metab. 2007 Apr;8(3):245-66.

31. Pereira JN. The plasma free fatty acid rebound induced by nicotinic acid. J Lipid Research 1967 Volume 8, 239-44.

32. Sainio EL, Sainio P. Comparison of effects of nicotinic acid or tryptophan on tryptophan 2,3-dioxygenase in acute and chronic studies. Toxicol Appl Pharmacol. 1990 Feb;102(2):251-8.

33. Salter M, Hazelwood R, Pogson CI, Iyer R, Madge DJ, Jones HT, Cooper BR, Cox RF, Wang CM, Wiard RP. The effects of an inhibitor of tryptophan 2,3-dioxygenase and a combined inhibitor of tryptophan 2,3-dioxygenase and 5-HT reuptake in the rat. Neuropharmacology. 1995 Feb;34(2):217-27.

34. Schroecksnadel K, Winkler C, Wirleitner B, Schennach H, Fuchs D. Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro. Clin Exp Immunol. 2005 Apr;140(1):41-5.

35. Struder HK, Hollmann W, Platen P, Duperly J, Fischer HG, Weber K. Alterations in plasma free tryptophan and large neutral amino acids do not affect perceived exertion and prolactin during 90 min of treadmill exercise. Int J Sports Med. 1996 Feb;17(2):73-9.

36. Struder HK, Hollmann W, Platen P, Wöstmann R, Ferrauti A, Weber K. Effect of exercise intensity on free tryptophan to branched-chain amino acids ratio and plasma prolactin during endurance exercise. Can J Appl Physiol. 1997 Jun;22(3):280-91.

37. Walsh HA, Daya S. Inhibition of hepatic tryptophan-2,3-dioxygenase: superior potency of melatonin over serotonin. J Pineal Res. 1997 Aug;23(1):20-3.

38. Wang R, Xu Y, Wu HL, Li YB, Li YH, Guo JB, Li XJ. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur J Pharmacol. 2008 Jan 6;578(1):43-50.

39. Young SN, Gauthier S. Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1981 Apr;44(4):323-8.